KMID : 0356920090570020203
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Korean Journal of Anesthesiology 2009 Volume.57 No. 2 p.203 ~ p.209
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The effects of inspiratory to expiratory ratio on ventilation and oxygenation during high frequency partial liquid ventilation in a rabbit model of acute lung injury
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Song Myung-Hee
Choi In-Cheol Hahm Kyung-Don Jeong Yong-Bo Choi Kyu-Taek
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Abstract
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Background: We examined the effects of varying inspiratory to expiratory (I£ºE) ratio on gas exchange and hemodynamics during high frequency partial liquid ventilation (HFPLV), a combination of high frequency ventilation (HFV) and partial liquid ventilation (PLV), in a rabbit model of acute lung injury.
Methods: Twelve rabbits treated with repeated saline lavage were divided into two groups. In the HFPL group (n = 6), 6 ml/kg of perfluorodecaline was administered through the endotracheal tube. Rabbits in this group and in the HFJ group (n = 6) were treated with high frequency jet ventilation (HFJV) at I£ºE ratios of 1£º1, 1£º2, and 1£º3 for 15 minutes, and arterial blood gas, mixed venous blood gas and hemodynamic parameters were measured.
Results: We observed no significant respiratory and hemodynamic differences between the two groups. At an I£ºE ratio of 1£º1, the PaO2 was significantly higher, and the shunt rate and PaCO2 were significantly lower in both groups, compared with I£ºE ratios of 1£º2 and 1£º3. Cardiac output at the 1£º3 I£ºE ratio was significantly higher than at 1£º1.
Conclusions: These findings indicate that, in this model, a 1£º1 I£ºE ratio was superior for oxygenation and ventilation than I£ºE ratios of 1£º2 or 1£º3, while having no detrimental effects on hemodynamics.
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KEYWORD
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Acute lung injury, Expiratory ratio, Gas exchange, High frequency jet ventilation, Inspiratory, Partial liquid ventilation, Perfluorocarbon
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